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참여교수 명단
참여교수 명단
정규혁 성명 정규혁                
직위구분 사업단장
연구실번호 031-290-7714
연구실주소 -
이메일 khchung@skku.edu
홈페이지
사업참여기간  
경력 1990 - 1994 : National Institute of Scientific Investigation, Korea (Senior Researcher)
1992 - 1995 : Louisiana State University (Visiting Fellow)
1995 - 1999 : College of Pharmacy, Sungkyunkwan University (Assistant Professor)
1999 - 2004 : College of Pharmacy, Sungkyunkwan University (Associate Professor)
2004 - Present : College of Pharmacy, Sungkyunkwan University (Professor)
2006 - 2008 : Dean of School of Pharmacy, Sungkyunkwan University
2006 - 2008 : Director of Graduate School of Clinical Pharmacy, Sungkyunkwan University
2011 - Present : Dean of School of Pharmacy, Sungkyunkwan University
2011 - Present : Director of Graduate School of Clinical Pharmacy, Sungkyunkwan University
논문 Organic extracts of urban air pollution particulate matter (PM 2.5)-induced genotoxicity and oxidative stress in human lung bronchial epithelial cells (BEAS-2B cells), (Oh S.M., Kim H.R., Park Y.J., Lee S.Y., Chung K.H.) Mutat. Res.-Gen. Tox. En. 723(2):142-151, 2011.

Feasibility of rat hair as a quality control material for the determination of methamphetamine and amphetamine in human hair (Lee S.Y., Park Y.H., Kim J.H., In S.H.,Choi H.K., Chung H.S., Oh S.M., Chung K.H.) Arch. Pharm. Res. 34(4):593-598, 2011.

A comparative analysis of the impact of a positive list system on new chemical entity drugs and incrementally modified drugs in South Korea (Ha D.M., Choi Y., Kim D.U., Chung K.H., Lee E.K) Clin. Ther. 33(7):926-932, 2011.

Determination of Illegally Abused sedative-hypnotics in hair samples from drug offenders (Lee SY, Han EY, In SH, Choi HK, Chung HS, Chung KH) J. Anal. Toxicol. 35(5):312-315, 2011.

Silver nanoparticles enhance thrombus formation through increased platelet aggregation and procoagulant activity (Jun E.A., Lim K.M., Kim K.Y., Bae O.N., Noh J.Y., Chung K.H., Chung J.H.) Natotoxicology. 5(2):157-167, 2011.

Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells (Kim H.R., Kim M.J., Lee S.Y., Oh S.M., Chung K.H.) Mutat Res-Gen Tox En 726(2):129-135, 2011.

Estimation of the measurement uncertainty by the bottom-up approach for the determination of methamphetamine and amphetamine in urine (Lee S.Y., Choi H.Y.,
Kim E.M., Choi H.K., Chung H.S., Chung K.H.) J. Anal. Toxicol. 34(4):222-228, 2010.

Molecular cloning of vitellogenin gene and mRNA expression by 17a-ethinylestradiol from slender bitterling (Kim H.R., Park Y.J., Kim J.G., Chung K.H., Oh S.M.) Gen. Comp. Endocr. 168(3):484-495, 2010.

Thebain in hair as a marker for chronic use of illegal opium poppy substances (Lee S.Y., Park Y.H., Han E.Y., Choi H.K., Chung H.S., Oh S.M., Chung K.H.) Forensic Sci. Int. 204(1-3):115-118, 2010.

Homogeneity and stability of candidate certified reference material for the determination of methamphetamine and amphetamine in hair (Lee S.Y., H Miyaguchi,Han E.Y., Kim E.M., Park Y.H., Choi H.K.,Chung H.S., Oh S.M., Chung K.H.) J. Pharmaceut. Biomed. 53(4):1037-1041, 2010.

Silver nanoparticles enhance thrombus formation through increased platelet aggregation and procoagulant activity (Jun E.A., Lim K.M., Kim K.Y., Bae O.N., Noh J.Y., Chung K.H., Chung J.H.) Natotoxicology. 5(2):157-167, 2010.

Simultaneous quantification of opiates and effect of pigmentation on its deposition (Lee S.Y., Han E.Y., Kim E.M., Choi H.K., Chung H.S., Oh S.M., Yun Y.M., Jwa S.H., Chung K.H.) Arch. Pharm. Res. 33(11):1805-1811, 2010.

Analysis of public hair as an alternative specimen to scalp hair: A contamination issue (Lee S.Y., Han E.Y., In S.H., Choi H.K., Chung H.S., Chung K.H.) Forensic Sci. Int. 206(1-3):19-21, 2010.

Detection of phentermine in hair samples from drug suspects (Lee S.Y., Kim J.H.,
In S.H., Choi H.K., Chung H.S., Chung K.H. ) Forensic Sci. Int. 207(1-3):e5-7, 2010.
전공분야 예방약학
연구주제 Cell model-based toxicology
Mechanisms and Strategies for cancer prevention
Risk assessment of inhaled toxicants and endocrine disruptors
참여교수 명단
이석용 성명 이석용                
직위구분 실무(책임)교수
연구실번호 031-290-7718
연구실주소 -
이메일 sylee@skku.ac.kr
홈페이지
사업참여기간  
경력 <교육 경력>
1982.3 - 1982.8 : 성균관대학교 약학대학 조교
1982.9 - 1988.2 : 가톨릭의과대학 약리학교실 조교
1988.3 - 1997.8 : 가톨릭의과대학 약리학교실 전임강사, 조교수, 부교수
1993.9 - 1995.6 : 미국 미네소타대학교 의과대학 교환교수
1997.9 - 2002.3 : 성균관대학교 약학대학 부교수 (약물학)
2002.4 - 현재 : 성균관대학교 약학대학 교수 (약물학)

<교내 활동>
성균관대학교 교과과정심의위원회 위원 (1998-2000)
성균관대학교 약학과 학과장 (2002-2004)
성균관대학교 자연과학캠퍼스발전기획위원회 위원 (2005-2007)
성균관대학교 예산결산자문위원회 위원 (2005-2007)
성균관대학교 공동기기운영위원회 위원 (2007-2013)
성균관대학교 기숙사 학사장 (2008-2010)
성균관대학교 Vision 2010+ 평가위원회 위원 (2010-2011)
(현) 성균관대학교 임상약학대학원 학과장 (1999.3 - )
(현) 성균관대학교 생명윤리위원회 부위원장 (2012.8 - )

<교외 활동>
가톨릭의과대학 외래교수 (1998-2006)
대한약사회 약학위원회 위원 (1998-2000)
보건복지부 의약품분류위원회 위원 (1999-2000)
학교법인 앞선학원 재단이사 (2004- )
대한약리학회 이사(2001-2004),상임이사(2005-2014), 재무이사(2007-2010)
식품의약품안전평가원 R&D기획단 운영위원 (2010)
삼성서울병원 임상시험심사위원회 심사위원(2010-2013)
대한약학회 임상약학특별위원회 위원 (2011-2012)
대한약학회 약물학분과회 회장 (2012)
(현) 성균관대학교 총동창회 부회장 (2011 - )
(현) 식약처 중앙약사심의위원회 위원 (1998.1 - )
(현) 식품의약품안전평가원 전문가 자문위원 (2009.10 - ), 의약품심사자문단(2013- ), 생동성관리정책자문단(2014- )
(현) 식품의약품안전청 의약품재분류 자문위원 (2011 - )
(현) 건강보험심사평가원 약제급여평가위원회 심사위원(2013.7 - ), 약리부 심사위원 (2004.8 - )
(현) 대한약리학회 총무이사 (2013.1 - )
(현) 대한약학회 교육위원회 위원장 (2013.1 - )
(현) 한국약학교육협의회 약사고시위원회 부위원장 (2014 - )
(현) 미국약리학회(ASPET) 정회원
(현) 미국임상약리학회(ASCPT) 정회원
(현) 대한약리학회 평의원
(현) 대한약학회 평생회원
(현) 대한임상약리학회 정회원
논문 67. Lee HI, Choi CI, Byeon JY, Lee JE, Park SY, Kim YH, Kim SH, Lee YJ, Jang CG, Lee SY. Simultaneous determination of flurbiprofen and its hydroxy metabolite in human plasma by liquid chromatography-tandem mass spectrometry for clinical application. J Chromatogr B. 971, 58-63, 2014.

66. Lee HI, Choi CI, Sa JH, Lee YJ, Bae JW, Jang CG, Lee SY. Ursodeoxycholic acid, an inhibitor of hepatocyte nuclear factor 1alpha, did not increase the systemic exposure of pitavastatin. Int J Clin Pharmacol Ther. 2014 Aug 20. [Epub ahead of print]

65. Lee HI, Bae JW, Choi CI, Lee YJ, Byeon JY, Jang CG, Lee SY. Response to Suarez-Kurtz's comments on strongly increased exposure of meloxicam in CYP2C9*3/*3 individuals. Pharmacogenet Genomics. 24(8):407-8, 2014.

64. Kwon SH, Ma SX, Lee SY, Jang CG. Sulfuretin inhibits 6-hydroxydopamine-induced neuronal cell death via reactive oxygen species-dependent mechanisms in human neuroblastoma SH-SY5Y cells. Neurochem Int. 74:53-64, 2014.

63. Nguyen TL, Kwon SH, Hong SI, Ma SX, Jung YH, Hwang JY, Kim HC, Lee SY, Jang CG. Transient receptor potential vanilloid type 1 channel may modulate opioid reward. Neuropsychopharmacology. 39(10):2414-22, 2014.

62. Kwon SH, Ma SX, Hong SI, Kim SY, Lee SY, Jang CG. Eucommia ulmoides Oliv. bark. attenuates 6-hydroxydopamine-induced neuronal cell death through inhibition of oxidative stress in SH-SY5Y cells. J Ethnopharmacol. 152(1):173-82, 2014.

61. Choi CI, Bae JW, Lee YJ, Lee HI, Jang CG, Lee SY. Effects of CYP2C19 genetic polymorphisms on atomoxetine pharmacokinetics. J Clin Psychopharmacol. 34(1):139-42, 2014.

60. Lee HI, Bae JW, Choi CI, Lee YJ, Byeon JY, Jang CG, Lee SY. Strongly increased exposure of meloxicam in CYP2C9*3/*3 individuals. Pharmacogenet Genomics. 24(2):113-7, 2014.

59. Kwon SH, Ma SX, Joo HJ, Lee SY, Jang CG. Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice. Biomol Ther 21(6):462-9, 2013.

58. Jung YH, Ha RR, Kwon SH, Hong SI, Lee KH, Kim SY, Lee SY, Jang CG. Anxiolytic effects of Julibroside C1 isolated from Albizzia julibrissin in mice. Prog Neuropsychopharmacol Biol Psychiatry. 44:184-92, 2013.

57. Lee SY, You IJ, Kim MJ, Kwon SH, Hong SI, Kim JH, Jang MH, Oh SM, Chung KH, Lee SY, Jang CG. The abuse potential of oxethazaine: effects of oxethazaine on drug-seeking behavior and analysis of its metabolites in plasma and hair in animal models. Pharmacol Biochem Behav. 105:98-104, 2013.

56. Choi CI, Bae JW, Keum SK, Lee YJ, Lee HI, Jang CG, Lee SY. Effects of OCT2 c.602C > T genetic variant on the pharmacokinetics of lamivudine. Xenobiotica. 43(7):636-40, 2013.

55. Choi CI, Park JI, Lee HI, Lee YJ, Jang CG, Bae JW, Lee SY. Determination of tolperisone in human plasma by liquid chromatography/tandem mass spectrometry for clinical application. J Chromatogr B Analyt Technol Biomed Life Sci. 911:59-63, 2012.

54. Choi CI, Lee HI, Bae JW, Lee YJ, Byeon JY, Jang CG, Lee SY. Determination of
tamsulosin in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 909:65-9, 2012.

53. Jung YH, Kwon SH, Hong SI, Lee SO, Kim SY, Lee SY, Jang CG. 5-HT(1A) receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia. Pharmacol Biochem Behav. 103(2):367-72, 2012.

52. Hong SI, Kwon SH, Kim MJ, Ma SX, Kwon JW, Choi SM, Choi SI, Kim SY, Lee SY, Jang CG. Anxiolytic-Like Effects of Chrysanthemum indicum Aqueous Extract in Mice: Possible Involvement of GABAA Receptors and 5-HT1A Receptors. Biomol Ther 20(4):413-7, 2012.

51. Kwon SH, Kim MJ, Ma SX, You IJ, Hwang JY, Oh JH, Kim SY, Kim HC, Lee SY, Jang CG. Eucommia ulmoides Oliv. Bark. protects against hydrogen peroxide-induced neuronal cell death in SH-SY5Y cells. J Ethnopharmacol. 142(2):337-45, 2012.

50. Bae JW, Choi CI, Lee HI, Lee YJ, Jang CG, Lee SY. Effects of CYP2C9*1/*3 and *1/*13 on the pharmacokinetics of losartan and its active metabolite E-3174. Int J Clin Pharmacol Ther. 50(9):683-9, 2012.

49. Choi CI, Bae JW, Jang CG, Lee SY. Tamsulosin exposure is significantly increased by the CYP2D6*10/*10 genotype. J Clin Pharmacol. 52(12):1934-8, 2012.

48. Choi CI, Bae JW, Lee HI, Jang CG, Sohn UD, Lee SY. Determination of atomoxetine metabolites in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 885-886:103-8, 2012.

47. Kwon SH, Hong SI, Jung YH, Kim MJ, Kim SY, Kim HC, Lee SY, Jang CG. Lonicera japonica THUNB. protects 6-hydroxydopamine-induced neurotoxicity by inhibiting activation of MAPKs, PI3K/Akt, and NF-κB in SH-SY5Y cells. Food Chem Toxicol. 50(3-4):797-807, 2012.

46. Choi CI, Lee YJ, Lee HI, Kim BH, Kim MJ, Jang CG, Bae JW, Lee SY. Effects of the SLCO1B1*15 allele on the pharmacokinetics of pitavastatin. Xenobiotica. 42(5):496-501, 2012.

45. You IJ, Jung YH, Kim MJ, Kwon SH, Hong SI, Lee SY, Jang CG. Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT₁A, GABA(A), and NMDA receptors. Neuropharmacology. 62(2):1034-43, 2012.

44. Choi CI, Kim MJ, Chung EK, Lee HI, Jang CG, Bae JW, Lee SY. CYP2C9*3 and *13 alleles significantly affect the pharmacokinetics of irbesartan in healthy Korean subjects. Eur J Clin Pharmacol. 68(2):149-54, 2012.

43. Wang Y, Park SY, Oh KH, Min Y, Lee YJ, Lee SY, Sohn UD. Characteristics of 5-hydroxytryptamine receptors involved in contraction of feline ileal longitudinal smooth muscle. Korean J Physiol Pharmacol. 15(5), 267, 2011.

42. Yan XM, Joo MJ, Lim JC, Whang WK, Sim SS, Im C, Kim HR, Lee SY, Kim IK, Sohn UD. The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression. Arch Pharm Res. 34(9), 1527, 2011.

41. Bae JW, Choi CI, Kim MJ, Oh DH, Keum SK, Park JI, Kim BH, Bang HK, Oh SG, Kang BS, Park HJ, Kim HD, Ha JH, Shin HJ, Kim YH, Na HS, Chung MW, Jang CG, Lee SY. Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics. Acta Pharmacol Sin. 32(10), 1303, 2011.

40. Choi CI, Kim MJ, Jang CG, Park YS, Bae JW, Lee SY. Effects of the CYP2C9*1/*13 genotype on the pharmacokinetics of lornoxicam. Basic Clin Pharmacol Toxicol. 109(6), 476, 2011.

39. Bae JW, Choi CI, Jang CG, Lee SY. Simultaneous determination of sibutramine and its active metabolites in human plasma by LC-MS/MS and its application to a pharmacokinetic study. Biomed Chromatogr. 25(11), 1181. 2011.

38. Bae JW, Jang CG, Lee SY. Effects of clopidogrel on the pharmacokinetics of sibutramine and its active metabolites. J Clin Pharmacol. 51(12), 1704, 2011.

37. Bae JW, Choi CI, Park SH, Jang CG, Lee SY. Analytical LC-MS/MS Method for Ezetimibe and Its Application for Pharmacokinetic Study. J. Liquid Chromatogr. Related Tech. 2011 in press.

36. Lee YH, Kim MJ, Choi CI, Bae JW, Jang CG, Lee SY. Retrospective study on antihyperlipidemic efficacy and safety of simvastatin, ezetimibe and their combination in Korean adults. Arch Pharm Res. 34, 1331, 2011

35. Tian YH, Hwan Kim S, Lee SY, Jang CG. Lactational and postnatal exposure to polychlorinated biphenyls induces sex-specific anxiolytic behavior and cognitive deficit in mice offspring. Synapse. 65, 1032, 2011.

34. Bae JW, Choi CI, Jang CG, Lee SY. Effects of CYP2C9*1/*13 on the pharmacokinetics and pharmacodynamics of meloxicam. Br J Clin Pharmacol. 71, 550, 2011

33. Lee KW, Kim HC, Lee SY, Jang CG. Methamphetamine-sensitized mice are accompanied by memory impairment and reduction of N-methyl-d-aspartate receptor ligand binding in the prefrontal cortex and hippocampus. Neuroscience. 178, 101, 2011

32. Kwon SH, Kim JA, Hong SI, Jung YH, Kim HC, Lee SY, Jang CG. Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells. Neurochem Int. 58, 533, 2011

31. Kwon SH, Hong SI, Kim JA, Jung YH, Kim SY, Kim HC, Lee SY, Jang CG. The neuroprotective effects of Lonicera japonica THUNB. against hydrogen peroxide-induced apoptosis via phosphorylation of MAPKs and PI3K/Akt in SH-SY5Y cells. Food Chem Toxicol. 49, 1011, 2011

30. Park JI, Choi CI, Jeon KJ, Bae JW, Jang CG, Lee SY. Association between ABCC2-24C>T 30. polymorphism and the pharmacokinetics of fexofenadine. Basic Clin. Pharmacol. Toxicol. 109(S1), 64, 2011.

29. Park JI, Choi CI, Bae JW, Jang CG, Lee SY. CYP2C9*3 allele markedly affects the pharmacokinetics and pharmacodynamics of meloxicam. Basic Clin. Pharmacol. Toxicol. 109(S1), 64, 2011.

28. Park JI, Choi CI, Bae JW, Jang CG, Lee SY. Effects of CYP2C9*13 allele on the pharmacokinetics of irbesartan. Basic Clin. Pharmacol. Toxicol. 109(S1), 64, 2011.

27. Keum SK, Choi CI, Bae JW, Jang CG, Lee SY. CYP2C9 genotype and dose optimization of celecoxib, a selective COX-2 inhibitor, in healthy Koreans. Clin. Pharmacol. Ther. 89, S45, 2011.

26. Park JI, Choi CI, Bae JW, Jang CG, Lee SY. Effects of CYP2D6*10/*10 genotype on the pharmacokinetics of atomoxetine and its metabolites. Basic Clin. Pharmacol. Toxicol. 109(S1), 64, 2011.

25. Oh DH, Bae JW, Choi CI, Jang CG, Lee SY. Effects of clopidogrel, CYP2B6 and CYP2C19 inhibitors, on the pharmacokinetics of sibutramine and its active metabolites. Clin. Pharmacol. Ther. 89, S19, 2011.

24. Choi CI, Bae JW, Jang CG, Lee SY. Dose adjustment of atomoxetine based on CYP2D6 genotype in healthy Koreans. Clin. Pharmacol. Ther. 89, S45, 2011.

23. Nguyen TL, Tian YH, You IJ, Lee SY, Jang CG. Modafinil-induced conditioned place preference via dopaminergic system in mice. Synapse. 65, 733, 2011

22. Kwon SH, Lee HK, Kim JA, Hong SI, Kim SY, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG. Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta(25-35)-induced learning and memory impairments in mice. Neurosci Lett. 487, 123, 2011

21. Bae JW, Choi CI, Lee JH, Jang CG, Chung MW, Lee SY. Effects of UDP-glucuronosyltransferase polymorphisms on the pharmacokinetics of ezetimibe in healthy subjects. Eur J Clin Pharmacol. 67, 39, 2011

20. Bae JW, Myung CS, Choi CI, Jang CG, Lee SY. HPLC assay method for ceftibuten in plasma and its application to pharmacokinetic study. J. Anal Chem. 65, 1261, 2010.

19. Kwon SH, Lee HK, Kim JA, Hong SI, Kim HC, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG. Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice. Eur J Pharmacol. 649, 210, 2010

18. Nguyen TL, Nam YS, Lee SY, Kim HC, Jang CG. Effects of capsazepine, a transient receptor potential vanilloid type 1 antagonist, on morphine-induced antinociception, tolerance, and dependence in mice. Br J Anaesth. 105, 668, 2010

17. Tian YH, Baek JH, Lee SY, Jang CG. Prenatal and postnatal exposure to bisphenol a induces anxiolytic behaviors and cognitive deficits in mice. Synapse. 64, 432, 2010

16. Bae JW, Kim MJ, Jang CG, Lee SY. Protective effects of heme oxygenase-1 against MPP(+)-induced cytotoxicity in PC-12 cells. Neurol Sci. 31, 307, 2010

15. Tian YH, Lee SY, Kim HC, Jang CG. Repeated methamphetamine treatment increases expression of TRPV1 mRNA in the frontal cortex but not in the striatum or hippocampus of mice. Neurosci Lett. 472, 61, 2010

14. Nguyen TL, You IJ, Oh S, Yang CH, Lee SY, Jang CG. Assessment of the rewarding effects of dimenhydrinate using the conditioned place preference paradigm in mice. Neurosci Lett. 471, 38, 2010

13. Yoo JH, Lee HK, Kim HC, Lee SY, Jang CG. GABA(A) receptors mediate the attenuating effects of a 5-HT(3) receptor antagonist on methamphetamine-induced behavioral sensitization in mice. Synapse. 64, 274, 2010

12. Joo KM, Nam GW, Park SY, Relationship Relationship between cutaneous barrier function and ceramide species in human stratum corneum. J. Dermatol. Sci. 60, 47, 2010.

11. Shin DW, Shim JH, Kim YK, Chitosan increases alpha 6 integrin(high)/CD71 human keratinocytr transit-amplifying cell population. Biomol. Ther. 18, 280, 2010.

10. Joo KM, Lee JH, Jeon HY, Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method. J. Pharm. Biomed. Anal. 51, 278, 2010.

9. Cha NR, Lee JK, Lee YR, Determination of iron, copper, zinc, lead, nickel and cadmium in cosmetic material by flame atomic absorption spectroscopt. Anal. Lett. 43, 259, 2010.

8. Kwon SH, Kim HC, Lee SY, Jang CG. Loganin improves learning and memory impairments induced by scopolamine in mice. Eur J Pharmacol. 619, 44, 2009

7. Choi CI, Bae JW, Moon SM, Song Y, Kim MJ, Jang CG, Lee SY. Effects of clarithromycin on the pharmacokinetics of pitavastatin. Basic Clin. Pharmacol. Toxicol. 105 (s.1), 70, 2009

6. Choi CI, Bae JW, Kim DH, Sa JH, Kim MJ, Jang CG, Lee SY. Effects of ursodeoxycholic acid, hepatic nuclear factor 1A inhibitor, on the pharmacokinetics of OATP1B1 substrate pitavastatin. Basic Clin. Pharmacol. Toxicol. 105 (s.1), 70, 2009

5. Choi CH, Bae JW, Lee HI, Kim MJ, Jang CG, Lee SY. Effects of SLCO1B1 genetic polymorphism on the pharmacokinetics of pitavastatin in Koreans. Basic Clin. Pharmacol. Toxicol. 105 (s.1), 79, 2009

4. Bae JW, Choi CI, Kim MJ, Jang CG, Lee SY. Effects of CYP2C19 haplotype on the pharmacokinetics and pharmacodynamics of omeprazole. Basic Clin. Pharmacol. Toxicol. 105 (s.1), 79, 2009

3. Choi CI, Bae JW, Kim MJ, Jang CG, Lee SY. Effects of UGT1A1 genetic polymorphism on the pharmacokinetics of ezetimibe. Basic Clin. Pharmacol. Toxicol. 105 (s.1), 79, 2009

2. Bae JW, Kim JH, Choi CI, Kim MJ, Kim HJ, Byun SA, Chang YS, Jang CG, Park YS, Lee SY. Effect of CYP2C9*3 allele on the pharmacokinetics of naproxen in Korean subjects. Arch Pharm Res. 32, 269, 2009

1. Bae JW, Kim NT, Choi CI, Kim MJ, Jang CG, Lee SY. HPLC analysis of plasma glipizide and its application to pharmacokinetic study. J. Liquid. Chromatogr. Related Technol. 32, 1969, 2009.
전공분야 약리학, 임상약리학, 약물치료학
연구주제 약물유전체학 (Pharmacogenomics)
심혈관계약리학 (Cardiovascular Pharmacology)
신경약리학 (Neuropharmacology)
Drug metabolism & Pharmacokinetics

약물유전체연구(Pharmacogenomics), 중추신경계약리(Neuropharmacology), 심혈관계약리(Cardiovascular Pharmacology)에 대하여 주로 연구 하고 있다. 약물유전체연구에서는 맞춤약물, 맞춤요법 및 진단용 microarray chip개발을 목표로 약물대사효소, 약물수송자 및 수용체 유전자의 다형성(Polymorphism)이 약물의 치료작용 및 부작용에 미치는 영향을 연구하며, 중추신경계약리에서는 신경전달물질의 작용기전 연구, 퇴행성질환의 발생기전과 치료약물 개발, 중추신경계약물들의 습관성•의존성 기전연구, 행동약리 등을 연구하고, 심혈관계약리에서는 고혈압의 발생기전과 조절에 대하여 연구하고 있다.

그외 여러약물들의 약효/약리평가, 생동성평가, PK평가 등을 수행한다.
- 경피제제(Patch제)의 약효평가
- 진통/소염/해열/혈소판응집억제제의 약효/약리 평가
- 관절염치료제의 약효/약리 평가
- 고혈압치료제의 약효/약리 평가
- 당뇨병치료제의 약효/약리 평가
- 고지혈증치료제의 약효/약리 평가
- 간세포보호제의 약효/약리 평가
- 위장관/혈관/기관지 평활근에 작용하는 약물 약효/약리 평가
- 행동약리 평가
- 일반약리 평가
- 생물학적동등성 평가
참여교수 명단
유선동 성명 유선동                
직위구분 참여교수
연구실번호 031-290-7757
연구실주소 -
이메일
홈페이지
사업참여기간  
경력 1989 - 1991 : Post-doctoral Fellow, University of Kentucky, COP, USA
1991 - 1997 : Assistant Professor, University of South Carolina, COP, USA
1997 - 2001 : Associate Professor, SKKU School of Pharmacy
2004 - 2006 : Dean, SKKU School of Pharmacy
2002 - 현재 : Professor, SKKU School of Pharmacy
논문 Shin B.S., Yoo S.D., Kim T.H., Bulitta J.B., Landersdorfer C.B., Shin J.C., Choi J.H., Weon K.Y., Joo S.H., Shin S. Quantitative determination of absorption and first-pass metabolism of apicidin, a potent histone deacetylase inhibitor. Drug Metab. Dispos. 42:974-982, 2014.

Kim T.H., Shin S., Bashir M., Chi Y.H., Paik S.H., Lee J.H., Choi H.J., Choi J.H., Yoo S.D., ulitta J.B., Ma E., Joo S.H., Shin B.S. Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats. Xenobiotica. 44:913-925, 2014.

Kim T.H., Shin B.S., Kim K.B., Shin S.W., Seok S.H., Kim M.K., Kim E.J., Kim D., Kim M.G., Park E.S., Kim J.Y., Yoo S.D. Percutaneous absorption, disposition and exposure assessment of homosalate, a UV filtering agent, in rats. J. Toxicol. Environ. Health Part A77:202-213, 2014.

Choi J.Y., Kim B.S., Kim C.H., Kim D.G., Han S.J., Lee K., Kim K.M., An G., Choi T.H., Yoo S.D., Ryu Y.H. Translational possibility of [18 F]Mefway to image serotonin 1A receptors in humans: Comparison with [18 F]FCWAY in rodents. Synapse 68:595-603, 2014.

Kim T.H., Shin B.S., Shin S.W., Seok S.H., Kim K.B., Kim E.J., Kim D., Kim D.H., Yoo W.Y., Yoo S.D. HPLC-MS/MS method for the pharmacokinetics of homosalate after topical administration in rats. J. Liquid Chromatogr. Rel. Technol. 37:2465-2477, 2014.

Hong J.Y., Lee B.H., Kim T.H., Hong J., Lee K.M., Yoo S.D., Lee H.S. GC-MS/MS method for the quantification of α-cedrene in rat plasma and its pharmacokinetic application. J. Sep. Sci. 36:3558-3562, 2013.

Kim T.H., Shin S., Shin J.C., Choi J.H., Seo W.S., Park G.Y., Kwon D.R., Yoo S.D., Lee A.R., Joo S.H., Min B.S., Shin B.S. Liquid chromatography-tandem mass spectrometry determination of baclofen in various biological samples and application to a pharmacokinetic study. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 938:43-50, 2013.

Choi Y., Shin B.S., Kim M.G., Shin S.W., Choo H.W., Kim T.H., Jang H.C., Yoo S.D. Micro-sample analysis of capsaicin by liquid chromatography-tandem mass spectrometry assay and application to oral absorption study. Acta Chromatographica 25:363-376, 2013.

Kim M.G., Shin B.S., Choi Y., Ryu J.K., Shin S.W., Choo H.W., Yoo S.D., Determination and pharmacokinetics of [6]-gingerol in mouse plasma by liquid chromatography-tandem mass spectrometry. Biomed. Chromatogr. 26:660-665, 2012.

Ryu J.K., Yoo S.D., Preparation and evaluation of bicyclol microemulsions for enhanced oral bioavailability. Drug Dev. Ind. Pharm. 38:1313-1318, 2012.

Ryu J.K., Yoo S.D., Simultaneous determination of levocetirizine and pseudoephedrine in dog plasma by liquid chromatography-mass spectrometry in the presence of dextrocetirizine. J. Pharm. Pharm. Sci. 15:519-527, 2012.

Liu Y., Yoo S.D., Li L., Fang L., Wen Z. Li T. Formulation and characterization of boanmycin-loaded liposomes prepared by pH gradient experimental design, Drug Deliv. 19:90-101, 2012.

Roh T., Kwak M.Y., Kwak E.H., Kim D.H., Han E.Y., Bae J.Y., Bang du Y., Lim D.S., Ahn I.Y., Jang D.E., Lim S.K., Yoo S.D., Kwack S.J., Park K.L., Lee Y.J., Kim K.B., Lee J., Kim H.S., Lee B.M. Chemopreventive mechanisms of methionine on inhibition of benzo(a)pyrene-DNA adducts formation in human hepatocellular carcinoma HepG2 cells. Toxicol. Lett. 208:232-238, 2012.

Shin B.S., Bulitta J.B., Hong D.K., Kim M.K., Choi Y., Lee J.B., Hwang S.W., Lee M.H., and Yoo S.D., Population pharmacokinetics of a novel histone deacetylase inhibitor, cyclo{(2S)-2-amino-8-[(aminocarbonyl)hydrazono] decanoyl-1-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl} (SD-2007), and its metabolic conversion to apicidin after intravenous injection and oral administration in rats. Chemotherapy 57:259-267, 2011.

Shin B.S., Bulitta J.B., Balthasar J.P., Kim M.K., Choi Y., Yoo S.D., Prediction of human pharmacokinetics and tissue distribution of apicidin, a potent histone deacetylase inhibitor, by physiologically-based pharmacokinetic modeling. Cancer Chemother. Pharmacol. 68:465-475, 2011.

Shin B.S., Kim T.H., Paik S.H., Chi Y.H., Lee J.H., Tan H.K., Choi Y., Kim M., Yoo S.D., Simultaneous determination of fimasartan, a novel antihypertensive agent, and its active metabolite in rat plasma by liquid chromatography-tandem mass spectrometry. Biomed. Chromatogr. 25:1208-1214, 2011.

Shanmugam S., Ryu J.K., Yoo S.D., Choi H.G., Woo J.S., Evaluation of pharmacokinetics of simvastatin and its pharmacologically active metabolite from controlled-release tablets of simvastatin in rodent and canine animal models. Biomol. Ther. 19:248-254, 2011.

Shin B.S., Hwang S.W., Bulitta J.B., Lee J.B., Yang S.D., Park J.S., Kwon M.C., Kim D.J, Yoon H.S., Yoo S.D. Assessment of bisphenol A exposure in Korean pregnant women by physiologically based pharmacokinetic modeling. J. Toxicol. Environ. Health A 73:1586-1598, 2010.

Liu Y., Yoo S.D., Fang L.A., Jin X., Li L., Li T.F., Ion-pair LC-UV method for the determination of boanmycin in mouse plasma and its application to a pharmacokinetic study. Chromatographia 72:357-359, 2010.

Shin B.S., Youn Y.S., Jeong S.H., Park E.S., Lee M.H., Yoo S.D., Current methologies for membrane permeability assessment. J. Pharm. Invest. 40:19-31, 2010.

Ji H.Y., Shin B.S., Jeong D.W., Park E.J., Park E.S., Yoo S.D., Lee H.S. Interspecies scaling of oleanolic acid in mice, rats, rabbits and dogs and prediction of human pharmacokinetics. Arch. Pharm. Res. 32:251-257, 2009.

Shin B.S., Yoon C.H., Balthasar J.P., Choi B.Y., Hong S.H., Kim H.J., Lee J.B., Hwang S.W., Yoo S.D. Prediction of drug bioavailability in humans using immobilized artificial membrane phosphatidylcholine column chromatography and in vitro hepatic metabolic clearance. Biomed. Chromatogr. 23:764-769, 2009.

Shin B.S., Kim H.J., Hong S.H., Lee J.B., Hwang S.W., Lee M.H., Yoo S.D. Enhanced absorption and tissue distribution of paclitaxel following oral administration of DHP 107, a novel mucoadhesive lipid dosage form. Cancer Chemother. Pharmacol. 64:87-94, 2009.

Lee K.C., Chun Y.G., Kim I., Shin B.S., Park E.S., Yoo S.D., Youn YS, Development and validation of a reversed-phase fluorescence HPLC method for determination of bucillamine in human plasma using pre-column derivatization with monobromobimane. J. Chromatogr. B 877:2130-2134, 2009.

Shin B.S., Hong S.H., Kim H.J., Yoo H.S., Kim D.J., Hwang S.W., Lee J.B., Yoo S.D., Development of a sensitive LC assay with fluorescence detection for the determination of zearalenone in rat serum. Chromatographia 69:295-299, 2009.

Shin B.S., Hong S.H., Hwang S.W., Kim H.J., Lee J.B., Yoon H.S., Kim D.J., Yoo S.D., Determination of zearalenone by liquid chromatography/tandem mass spectrometry and application to a pharmacokinetic study. Biomed. Chromatogr. 23:1014-1021. 2009.

Liu Y., Yoo S.D., Fang L., Jin X., Li L., Ren Y., Yoo C., Li T., Determination of boanmycin in pharmaceutical preparations by a simple and rapid ion-pair LC method. Chromatographia 70:643-646, 2009.

Shin B.S., Hong S.H., Bulitta J.B., Lee J.B., Hwang S.W. , Kim H.J., Yang S.D., Yoon H.S ., Kim D.J., Lee B.M., Yoo S.D., Physiologically based pharmacokinetics of zearalenone. J. Toxicol. Environ. Health A 72:1395-1405, 2009.

Shin B.S., Hong S.H., Bulitta J.B., Hwang S.W., Kim H.J., Lee J.B., Yang S.D., Kim J.E., Yoon H.S., Kim D.J., Yoo S.D., Disposition, oral bioavailability, and tissue distribution of zearalenone in rats at various dose levels. J. Toxicol. Environ. Health A 72:1406-1411, 2009.

Shin B.S., Seo J.H., Hur M.W., Lee M.N., Yoo S.D. Pharmacokinetics of GST-TatdMt, a recombinant fusion protein possessing potent anti-obesity activity, in mice. Arch. Pharm. Res. 30:1162-1167, 2007.

Shin B.S., Kim J.J., Kim J., Hu S.K., Kim H.J., Hong S.H., Kim H.K., Lee H.S., Yoo S.D. Oral bioavailability and enterohepatic recirculation of otilonium bromide in rats. Arch. Pharm. Res. 31:117-24, 2008.

Cao D., Kitamura T., Todo H., Yoo S.D., Sugibayashi K. Pretreatment effects of moxibustion on the skin permeation of FITC-dextran. Int. J. Pharm. 354:117-125, 2008.

Shin B.S., Choi J.W., Balthasar J.P., Hong D.K., Kim J.J., Yoo S.D., Determination of roxatidine in human plasma by liquid chromatography/ electrospray mass spectrometry and application to a clinical study. Rapid Commun. Mass Spectrom. 21:1-7, 2007.

Jeong D.W., Kim Y.H., Kim H.H., Ji H.Y., Yoo S.D., Choi W.R., Lee S.M., Han C.K., Lee H.S., Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats. Biopharm. Drug Dispos. 28:51-57, 2007.

Shin B.S., Kim C.H., Lee M.N., Hur M.W., Lee K.C., Youn Y.S., Yoo S.D., Pharmacokinetics of 125I-GST-TatdMt, a recombinant fusion protein possessing potent anti-obesity activity, after intravenous, nasal, oral, and subcutaneous administration, Reg. Pept. 140:74-80, 2007.

Shin B.S., Yoo S.D., Determination of clopidogrel in human plasma by liquid chromatography tandem mass spectrometry: application to a clinical pharmacokinetic study. Biomed. Chromatogr. 21:883-889, 2007.

Ryu J.Y., Whang J., Park H., Im J.Y., Kim J., Ahn M.Y., Lee J., Kim H.S., Lee B.M., Yoo S.D., Kwack S.J., Oh J.H., Park K.L., Han S.Y., Kim S.H. Di(2-ethylhexyl) phthalate induces apoptosis through peroxisome proliferators-activated receptor-gamma and ERK 1/2 activation in testis of Sprague-Dawley rats. J. Toxicol. Environ. Health A 70:1296-1303, 2007.

Lim D.S., Shin B.S., Yoo S.D., Kim H.S., Kwack S.J., Ahn M.Y., Lee B.M. Toxicokinetics of phthalic acid: the common final metabolite of phthalic acid esters in rats. J. Toxicol. Environ. Health A 70:1344-1349, 2007.

Shin B.S., Hu S.K., Kim J., Oh J.G., Youn W.N., Lee B., Um K.A., Kim D.K., Lee J.Y., Yoo S.D. Development of LC/MS/MS assay for the determination of 5-ethyl-2-{5-[4-(2-hydroxyethyl)piperazine-1-sulfonyl]-2-propoxyphenyl}-7-propyl-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one (SK3530) in human plasma: application to a clinical pharmacokinetic study. J. Pharm. Biomed. Anal. 45:176-184, 2007.

Kim Y.H., Yoo S.D., Kim Y.S., Lee K.H., Lee H.S. Dose-dependent pharmacokinetics of a new Na+/H+ exchanger inhibitor KR-33028 in rats. Biopharm. Drug Dispos. 28:423-429, 2007.

Shin B.S., Chang H.S., Park E.H., Yoon C.H., Kim H.Y., Kim J., Ryu J.K., Zee O.P., Lee K.C., Cao D., Yoo S.D., Pharmacokinetics of a novel histone deacetylase inhibitor, apicidin, in rats. Biopharm. Drug Dispos. 27:69-75, 2006.

Youn Y.S., Jung J.Y., Oh S.H., Yoo S.D., Lee K.C., Improved intestinal delivery of salmon calcitonin by Lys 18-amine specific PEGylation: stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy. J. Cont. Rel. 114:334-342, 2006.

Jeong D.w., Kim Y.H., Kim H.H., Ji H.Y., Yoo S.D., Choi W.R., Lee S.M., Han C.K., Lee H.S. Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats. Biopharm. Drug Dispos. 27:1-7, 2006.

Yuen M.F., Kim J., Kim C.R., Ngai V., Yuen J.C., Min C., Kang H.M., Shin B.S., Yoo S.D., Lai C.L., A randomized placebo-controled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antiviral Ther. 11:977-983, 2006.

Yoon C.H., Kim S.J., Shin B.S., Lee K.C., .Yoo S.D., Rapid screening of blood-brain barrier penetration of drugs using the immobilized artificial membrane phosphatidylcholine column chromatography. J. Biomol. Screen. 11:13-20, 2006
전공분야 약물동력학
연구주제 - Basic and Clinical Pharmacokinetics
- Rapid Screening of Drug Absorption Potential
- Physiologically-Based Pharmacokinetic Modeling
- Pharmacokinetic-Pharmacodynamic Modeling
참여교수 명단
이병무 성명 이병무                
직위구분 참여교수
연구실번호 031-290-7748
연구실주소 -
이메일 bmlee@skku.ac.kr
홈페이지
사업참여기간  
경력 1989 - 1990 : The Johns Hopkins University, Post-doc
1989 - 1990 : Sungkyunkwan University, Professor
1997 : (미) National Inst. Environ Health Sci (NIEHS), 객원연구원
2011 - 현재 : Korean Soc. of Toxicology (KSOT), President
2011 - 현재 : Korean Environ. Mutagen Society (KEMS), President
2011 - 2013 : 2013 ICT XIII Seoul Organizing Committee, President/Organizer
2010 - 현재 : J. Toxicol. Environ Health (JTEH), Food & Chemical Toxicol. (FCT): Associate Editor, Environ. Health Perspect (EHP): Editorial Board Member
논문 Lee, B.M. Evaluation Criteria for Publishing in Top-Tiered Journals in Environmental Health Sciences and Toxicology. Environ Health Perspect. 119:896-899. (2011)

Kang, S.C., Kim, H.W., Kim, K.B., Kwack, S.J., Ahn, I.Y., Bae, J.Y., Lim, S.K., Lee, B.M. Hepatotoxicity and Nephrotoxicity Produced by 4-Hydroxy-2-Nonenal (4-HNE) Following 4-Week Oral Administration to Sprague-Dawley Rats. J Toxicol Environ Health A. 74(12):779-789, (2011)

Kim KB, Um SY, Chung MW, Jung SC, Oh JS, Kim SH, Na HS, Lee BM, Choi KH. Toxicometabolomics approach to urinary biomarkers for mercuric chloride (HgCl)-induced nephrotoxicity using proton nuclear magnetic resonance (¹H NMR) in rats. Toxicol Appl Pharmacol. 249(2):114-26. (2010).

전공분야 독성학
연구주제 Carcinogenesis, - Cancer Chemoprevention,
Systems Toxicology (Toxicogenomics, Toxicoproteomics, Metabolomics)
Development of Nutraceuticals, Cosmetics, and New Drugs
Detox, Safety Evaluation, Risk Assessment & Endocrine Disruption
Development of New Biomarkers
참여교수 명단
이강노 성명 이강노                
직위구분 참여교수
연구실번호 031-290-7748
연구실주소 -
이메일 krlee@yurim.skku.ac.kr
홈페이지
사업참여기간  
경력 1983-1985 Daewoong Research Institute

1989-1990 Korea Institute of Science and Technology (KIST)

1991-1995 College of Pharmacy, Sungkyunkwan University (Assistant Professor)

1995-2000 College of Pharmacy, Sungkyunkwan University (Associate Professor)

2000-Present College of Pharmacy, Sungkyunkwan University (Professor)
논문 K.H. Kim, S.U. Choi, Y.C. Kim, and K.R. Lee, Tirucallane triperpenoids from Cornus walteri, J. Nat. Prod., 74, 54-59. (2011)

K.H. Kim, E. Moon, S.U. Choi, S.Y. Kim, and K.R. Lee, Biological evaluation of phenolic constituents from the trunk of Berberis koreana, Bioorg. Med. Chem. Lett., 21, 2270-2273. (2011)

I.K. Lee, K.H. Kim, S.Y. Lee, S.U. Choi, and K.R.Lee, Three new megastigmane glucopyranosides from the cardamine komarovii, Chem. Pharm. Bull., 59(6) 773-777. (2011)

M.C. Yang, H.C. Kwon, Y.J. Kim, K.R. Lee, and H.O. Yang, Oploxynes A and B, polycaetylenes from the stems of Oplopanax elatus, J. Nat. Prod., 73, 801-805. (2010)

K.H. Kim, C.J. Piao, S.U. Choi, M.W. Son, and K.R. Lee, New cytotoxic tetrahydroprotoberberine-apophine dimeric and apophine alkaloids from Corydalis turtschaninovii, Planta Med., 76, 1732-1738. (2010)
전공분야 천연물약품화학
연구주제 Isolation and structural determination of bioactive natural products

Terpenoids of Compositae

Cytotoxic constituents of natural products

Peroxide constituents from natural sources

참여교수 명단
정영훈 성명 정영훈                
직위구분 참여교수
연구실번호 031-290-7711
연구실주소 -
이메일 yhjung@skku.ac.kr
홈페이지
사업참여기간  
경력 1989 - 1990 : 미국 Harvard University 화학과 박사후연구원
1990 - 1993 : 동덕여자대학교 약학대학 조교수
1994 - 1999 : 성균관대학교 약학대학 부교수
1999 - 현재 : 성균관대학교 약학대학 교수
2001 - 2002 : 미국 University of California, Los Angeles, 화학과 교환교수
논문 - S. H. Lee, I. S. Kim, Q. R. Li, G. R. Dong, L. S. Jeong, Y. H. Jung, “Stereoselective amination of chiral benzylic ethers using chlorosulfonyl isocyanate: Total synthesis of (+)-Sertraline” J. Org. Chem. in press, 2011.

- S. H. Lee, I. S. Kim, Q. R. Li, G. R. Dong, Y. H. Jung, “Novel synthetic method for allylic amination of cyclic allylic ethers using chlorosulfonyl isocyanate” Tetrahedron Letters 52, 1901-1904, 2011.

- I. S. Kim, Q. R. Li, G. R. Dong, Y. C. Kim, Y. J. Hong, M. Lee, K-W. Chi, J. S. Oh, Y. H. Jung, “A Facile synthesis of Lentiginosine analogues based on a highly regio- and diastereoselective allylic amination using chlorosulfonyl isocyanate” Eur. J. Org. Chem. 1569-1573, 2010.

- I. S. Kim, Q. R. Li, G. R. Dong, S. H. Woo, Y. H. Jung, “A concise synthesis of (+)-Polyoxamic acid and (+)-5-O-carbamoyl polyoxamic acid” Synlett, 2985-2988, 2008.

- I. S. Kim, G. R. Dong, Y. H. Jung, “Palladium(II)-catalyzed isomerization of olefins with tributyltin hydride” J. Org. Chem. 72, 5424-5426, 2007.

- I. S. Kim, O. P. Zee, Y. H. Jung, “Regioselective and Diastereoselective Amination of Polybenzyl Ethers Using Chlorosulfonyl Isocyanate: Total Syntheses of 1,4-Dideoxy-1,4-imino-D-arabinitol and (-)-Lentiginosine” Organic Letters 8, 4101-4104, 2006
전공분야 유기약화학
연구주제 - Development of novel organic reactions
- Development of efficient synthetic routes
- Synthesis of biologically active alkaloids (azasugars)
- Asymmetric total synthesis using chlorosulfonyl isocyanate reaction
참여교수 명단
이선미 성명 이선미                
직위구분 참여교수
연구실번호 031-290-7712
연구실주소 -
이메일
홈페이지
사업참여기간  
경력 1983 - 1989 : 연세대학교 의과대학 조교 및 연구강사
1989 - 1992 : The Johns Hopkins University School of Medicine Postdoctoral Fellow
1992 - 현재 : 성균관대학교 약학대학 교수
1996 - 현재 : 보건복지부 중앙약사심의위원
2000 - 현재 : 한국응용약물학회 편집위원장, 학술위원장, 간사장 및 부회장
2001 - 2002 : The University of North Carolina 방문교수
논문 Kim TH, Lee SH, Lee SM "Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction" FEBS Journal 278, 2307-2317, 2011

Kang JW, Koh EJ, Lee SM “Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway” Journal of Pineal Research 50, 403-411, 2011

Kim HY, Park J, Lee KH, Lee DU, Kwak JH, Kim YS, Lee SM "Ferulic acid protects against carbon tetrachloride-induced liver injury in mice" Toxicology 282, 104-111, 2011

Kim SJ, Moon YJ, Lee SM "Protective effects of baicalin against ischemia/reperfusion injury in rat liver" Journal of Natural Products 73, 2003-2008, 2010

Yun N, Eum HA, Lee SM “Protective role of heme oxygenase-1 against liver damage caused by hepatic ischemia and reperfusion in rats” Antioxidant & Redox signaling 13, 1503-1512, 2010
전공분야 병태생리학
관심분야 Drug efficacy evaluation in preclinical approach
Pharmacological intervention for hepatic ischemia and reperfusion
New drug development for sepsis and inflammatory diseases
Organ preservation and pathogenesis for liver transplantation
Cell signaling pathway for pattern recognition receptors
참여교수 명단
박은석 성명 박은석                
직위구분 참여교수
연구실번호 031-290-7715
연구실주소 -
이메일
홈페이지
사업참여기간  
경력 1995-1996 Research Institute for Pharmaceutical Sciences and Research Scientist,

Basic Science Research Center, Sungkyunkwan University (Research Scientist)

1996-2000 College of Pharmacy, Sungkyunkwan University (Assistant Professor)

2000-2006 College of Pharmacy, Sungkyunkwan University (Associate Professor)

2004-2006 Pharmaceutical Society of Korea (Associate Editor of Archives of Pharmacal Research)

2006-Present College of Pharmacy, Sungkyunkwan University (Professor)

2006-present Phamaceutical Society of Korea (Editor of APR)
논문 Rhee YS, Park CW, Kim KJ, Chi SC, Park ES., Behavior of itraconazole and benzyl alcohol in aqueous solution containing nonionic surfactants. Arch Pharm Res. 30(2):240-8. (2007)



Rhee YS, Park CW, Nam TY, Shin YS, Chi SC, Park ES., Formulation of parenteral microemulsion containing itraconazole, Arch Pharm Res. 30(1):114-23 (2007)



D.C.Son, N.Thuong, E.-S. Park and S.-C. Chi. High Performance Liquid Chromatographic Analysis of Rebamipide in Human Plasma. Analytical Letters. 38:997-1005 (2005)



Kim SC, Yoon HJ, Lee JW, Yu JW, Park ES, Chi SC. Investigation of the release behavior of DEHP from infusion sets by paclitaxel-loaded polymeric micelles. International Journal of Pharmaceutics. 293:303-310 (2005)



Kim SC, Yu J, Lee JW, Park ES, Chi SC. Sensitive HPLC method for quantitation of paclitaxel(Genexol) in biological samples with application to preclinical pharmacokinetics and biodistribution. Journal of Pharmaceutical and Biomedical Analysis. 39(12):170-176 (2005)

전공분야 물리약학
연구주제 Preformulation

Development of polymeric drug delivery systems

Formulation of nano-and micro-particulates

Formulation of macro- & microemulsions

Stability study
참여교수 명단
장춘곤 성명 장춘곤                
직위구분 참여교수
연구실번호 031-290-7770
연구실주소 -
이메일 jang@skku.ac.kr
홈페이지
사업참여기간  
경력 연구경력
1996 - 1999 : Research Associate, University of Mississippi Medical Center, USA
2000 - 2001 : Research Assistant Professor, School of Medicine, Hallym University
2001 - 2005 : Assistant Professor, Sungkyunkwan University
2005 - 2011 : Associate Professor, Sungkyunkwan University
2009 - 2010 : Visiting Prosessor, The Scripps Research Institute, USA
2011 - 현재 : Professor, Sungkyunkwan University

학회활동
1996 : 미국 신경과학회 정회원
1987 : 대한약학회 정회원, 학술간사, 총무간사
1996 : 대한약리학회 정회원
2000 : 한국뇌신경과학회 정회원
2002 : 한국응용약물학회 정회원, 학술간사
2003 : Biomolecules & Therapeutics (SCIE) 편집위원
2005 : 한국약물남용학회 학술이사
2005 : 뇌기능연구사업단 홍보위원
2001 : 중앙약사심의위원회 마약분과 심의위원
2010 : 한국약학교육협의회 총무재정위원회간사
2011 : 한국응용약물학회 국제협력위원장

수상
2004 : 보건복지부 장관 표창
2010 : 한국응용약물학회 학술장려상
논문 Yoo JH, Lee HK, Kim HC, Lee SY, Jang CG. GABA(A) receptors mediate the attenuating effects of a 5-HT(3) receptor antagonist on methamphetamine-induced behavioral sensitization in mice. Synapse. 2010 Apr;64(4):274-279.

Bae JW, Kim MJ, Jang CG, Lee SY. Protective effects of heme oxygenase-1 against MPP(+)-induced cytotoxicity in PC-12 cells. Neurol Sci. 2010 Jun 31(3):307?313.

Tian YH, Baek JH, Lee SY, Jang CG. Prenatal and postnatal exposure to bisphenol A induces anxiolytic behaviors and cognitive deficits in mice. Synapse. 2010 Jun;64(6):432-439.

Nguyen TL, Nam YS, Lee SY, Kim HC, Jang CG. Effects of capsazepine, a transient receptor potential vanilloid type 1 antagonist, on morphine-induced antinociception, tolerance, and dependence in mice. Br J Anaesth. 2010 Nov;105(5):668-674.

Kwon SH, Lee HK, Kim JA, Hong SI, Kim HC, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG. Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice. Eur J Pharmacol. 2010 Dec 15;649(1-3):210-217.

Kwon SH, Lee HK, Kim JA, Hong SI, Kim SY, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG. Neuroprotective effects of Eucommia ulmoides Oliv. Bark on Amyloid beta(25-35)-induced learning and memory impairments in mice. Neurosci Lett. 2011;487:123-127.
전공분야 신경약리학
연구주제 Neuropharmacology
Neurochemical study for rewarding effects of drugs of abuse
Drug development for neurodegenerative disease (Depression, Anxiety, Parkinson)
참여교수 명단
김형식 성명 김형식                
직위구분 참여교수
연구실번호 031-290-7789
연구실주소 -
이메일 hkims@skku.edu
홈페이지
사업참여기간  
경력 2012.09 - 2013.03 : Professor , College of Pharmacy, Pusan National University.
2007.09 - Now : Associate Professor, College of Pharmacy, Pusan National University.
2006.03 - 2009.02 : Vice Dean, College of Pharmacy, Pusan National University.
2003.09 - 2007.08 : Assistant Professor, College of Pharmacy, Pusan National University
2002.02 - 2003.09 : Visiting Fellow in National Institutes of Health (NIH), USA
1997.04 - 2003.09 : Senior Scientist, Endocrine Toxicology Division, National Institute of
Toxicological Research (NITR), Korea Food and Drug Administration, Korea
1994.03 - 1996.08 : Teaching Assistance, College of Pharmacy, Sungkyunkwan University, Suwon, Korea
논문 Kim TH, Shin YJ, Won AJ, Choi WS, Jung JH, Lee JW, Kim HS. Resveratrol potentiates inhibition of doxorubicin-induced cancer cells migration or invasion in human breast cancer cell lines. Mol. Nut. Food Res, 2012, submit.

Li JL, Xiao B, Park M, Yoo ES, Shin S, Hong J, Chung HY, Kim HS, Jung JH. PPAR-γ Agonistic Metabolites from the Ascidian Herdmania momus. J. Nat. Prod., 2012 Nov 28. [Epub ahead of print]

Kim DK, Kim HS, Kim AR, Kim JH, Kim B, Noh G, Kim HS, Beaven MA, Kim YM, Choi WS. DJ-1 regulates mast cell activation and IgE-mediated allergic responses. J. Allergy Clin,. Immunol., 2012 Nov 22. doi:pii: S0091-6749(12)01656-9.

Lee YJ, Won AJ, Lee J, Jung JH, Yoon S, Lee BM, Kim HS. Molecular Mechanism of SAHA on Regulation of Autophagic Cell Death in Tamoxifen-Resistant MCF-7 Breast Cancer Cells. Int. J. Med. Sci. 2012; 9(10):881-93.

Kim JH, Tae Young Kim TY, Kim HS, Hong S and Yoon S. Lower Salinomycin Concentration Increases Apoptotic Detachment in High-Density Cancer Cells. Int. J. Mol. Sci. 2012, 13, 13169-13182.

Hwang HJ, Kang YJ, Hossain MA, Kim DH, Jang JY, Lee SH, Yoon JH, Moon HR, Kim HS, Chung HY, Kim ND. Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces apoptosis and cell cycle arrest in HCT116 human colon cancer cells. Int. J. Oncol. 2012,41(6):2057-64

Yoon S, Kim JH, Lee YJ, Choi G, Yang Z, Lee HJ, Moon HR, Kim HS. A novel carbazole derivative, MHY407, sensitizes breast cancer cells to doxorubicin-, etoposide-, and radiation-treatment via DNA damage and cell cycle arrest. Eur. J. Pharmacol. 2012, 697(1-3):24-31

Ahn MY, Na YJ, Lee J, Jeung HY, Kim HS. Apicidin inhibits human ovarian cancer cells migration and invasion through class II histone deacetylase (HDAC) 4 silencing. Cancer Letters, 2012; 325(2):189-99.

Bang DY, Kyung M, Kim MJ, Jung BY, Cho MC, Choi SM, Kim YW, Lim SG, Lim DS, Won AJ, Kwack SJ, Lee YK, Kim HS, Lee BM. Human Risk Assessment of Endocrine-Disrupting Chemicals Derived from Plastic Food Containers. CRFSFS. 2012, 11; 453-470.

Wang J, Kim TH, Ahn MY, Lee J, Jung JH, Choi WS, Lee BM, Yoon KS, Yoon S, Kim HS. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int. J. Oncol. 2012; 41(3):1101-1109.

Kim TH, Lim HJ, Lee YJ, Shin YJ, Ahn MY, De U, Lee JW, Lee BM, Kim S, Kim HS. Evaluation of metabolomic profiling against renal toxicity in Sprague-Dawley rats treated with melamine and cyanuric aciD. Arch. Toxicol., 2012, 86:1885-1897.

Kim KB, Yang JY, Kwack SJ, Kim HS, Ryu DH, Kim YJ, Bae JY, Lim DS, Choi SM, Kwon MJ, Bang DY, Lim SK, Kim YW, Hwang GS, Lee BM. Potential metabolomic biomarkers for evaluation of adriamycin efficacy using a urinary (1) H-NMR spectroscopy. J. Appl. Toxicol. 2012 Jul 11. doi: 10.1002/jat.2778. [Epub ahead of print].

Dang HT, Lee YM, Kang GJ, Yoo ES, Hong J, Lee SM, Lee SK, Pyee Y, Chung HJ, Moon HR, Kim HS, Jung JH. In vitro stability and in vivo anti-inflammatory efficacy of synthetic jasmonates. Bioorg. Med. Chem. 2012; 20(13):4109-16.

Jang YJ, Park HR, Kim TH, Yang WJ, Lee JJ, Choi SY, Oh SB, Lee E, Park JH, Kim HP, Kim HS, Lee J. High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations. Toxicology. 2012; 296(1-3):73-82.

Lee HK, Kim TS, Kim CY, Kang IH, Kim MG, Kyung Jung K, Kim HS, Han SY, Yoon HJ, Rhee GS. Evaluation of in vitro screening system for estrogenicity: comparison of stably transfected human estrogen receptor-α transcriptional activation (OECD TG455) assay and estrogen receptor (ER) binding assay. J. Toxicol. Sci. 2012; 37(2):431-437.

Kim HS, Kim AR, Lee JM, Kim SN, Choi JH, Kim do K, Kim JH, Kim B, Her E, Yang YM, Kim HS, Kim YM, Choi WS. JNK activation by upregulation of iNOS upon cholesterol accumulation limits neurogenesis and induces region specific DNA damage responses in the SVZ of NPC mice. J. Pharm. Pharmacol. 2012; 64(3):420-429.

Kim TH, Bang du Y, Lim HJ, Won AJ, Ahn MY, Patra N, Chung KK, Kwack SJ, Park KL, Han SY, Choi WS, Han JY, Lee BM, Oh JE, Yoon JH, Lee J, Kim HS. Comparisons of polybrominated diphenyl ethers levels in paired South Korean cord blood, maternal blood, and breast milk samples. Chemosphere. 2012; 87(1):97-104.

Roh T, Kwak MY, Kwak EH, Kim DH, Han EY, Bae JY, Bang du Y, Lim DS, Ahn IY, Jang DE, Lim SK, Yoo SD, Kwack SJ, Park KL, Lee YJ, Kim KB, Lee J, Kim HS, Lee BM. Chemopreventive mechanisms of methionine on inhibition of benzo(a)pyrene-DNA adducts formation in human hepatocellular carcinoma HepG2 cells. Toxicol. Lett. 2012; 208(3):232-238.

Kim HS, Je JH, Son TG, Park HR, Ji ST, Pokharel YR, Jeon HM, Kang KW, Kang HS, Chang SC, Kim HS, Chung HY, Lee J. The hepatoprotective effects of adenine nucleotide translocator-2 against aging and oxidative stress. Free Radic. Res. 2012; 46(1):21-9

Park JH, Ahn MY, Kim TH, Yoon S, Kang KW, Lee J, Moon HR, Jung JH, Chung HY, Kim HS. A new synthetic HDAC inhibitor, MHY218, induces apoptosis or autophagy-related cell death in tamoxifen-resistant MCF-7 breast cancer cells. Invest New Drugs. 2012; 30:1887-1898.

Kim MS, Park HR, Chung HY, Kim HS, Yu BP, Yang HS, Lee J. Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis. Chem. Biol. Interact. 2011; 194(2-3):139-47.

Kim ME, Park HR, Gong EJ, Choi SY, Kim HS, Lee J. Exposure to bisphenol A appears to impair hippocampal neurogenesis and spatial learning and memory. Food Chem Toxicol. 2011; 49(12):3383-9.

Park KL, Ko NY, Lee JH, Kim do K, Kim HS, Kim AR, Her E, Kim B, Kim HS, Moon EY, Kim YM, Kim HR, Choi WS. 4-Chlorotetrazolo[1,5-a]quinoxaline inhibits activation of Syk kinase to suppress mast cells in vitro and mast cell-mediated passive cutaneous anaphylaxis in mice. Toxicol Appl Pharmacol. 2011; 257(2):235-41.

Kim UJ, Lee IS, Kim HS, Oh JE. Monitoring of PBDEs concentration in umbilical cord blood and breast milk from Korean population and estimating the effects of various parameters on accumulation in humans. Chemosphere. 2011; 85(3):487-93

Kang JA, Yang Z, Lee JY, De U, Kim TH, Park JY, Lee HJ, Park YJ, Chun P, Kim HS, Jeong LS, Moon HR. Design, synthesis and anticancer activity of novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivatives. Bioorg. Med. Chem. Lett. 2011; 21(19):5730-4

Liu J, Li F, Kim EL, Li JL, Hong J, Bae KS, Chung HY, Kim HS, Jung JH. Antibacterial polyketides from the jellyfish-derived fungus Paecilomyces variotii. J. Nat. Prod. 2011;74(8):1826-9.

Patra N, De U, Kang J-A, Kim JM, Ahn MY, Moon HR, Jung JH, Chung HY, Kim HS. A novel epoxypropoxy flavonol derivative topoisomerase II inhibitor, MHY336, induces apoptosis in prostate cancer cells. Eur. J. Pharmacol, 2011; 658(2-3):98-107.

Dang HT, Kang GJ, Yoo ES, Hong J, Choi JS, Kim HS, Chung HY, Jung JH. Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads. Bioorg Med Chem. 2011; 19(4):1520-7.

Phuong NT, Kim SK, Lim SC, Kim HS, Kim TH, Lee KY, Ahn SG, Yoon JH, Kang KW. Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells. Breast Cancer Res. Treat. 2011; 130(1):73-83.

Lee YJ, Ahn MY, Kim HS, Kwack SJ, Park KL, Yoon S, Min D. Role of phospholipase D in regulation of testicular Leydig cell hyperplasia in Sprague-Dawley rats treated with di(2-ethylhexyl) phthalate. Arch. Toxicol. 2011; 85(8):975-85.

Kim JH, Chae M, Kim WK, Kim YJ, Kang HS, Kim HS, Yoon S. Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein. Br. J. Pharmacol. 2011; 162(3):773-84.

Kang DW, Park MH, Lee YJ, Kim HS, Lindsley CW, Brown HA, Min DS. Autoregulation of phospholipase D activity is coupled to selective induction of phospholipase D1 expression to promote invasion of breast cancer cells. Int. J. Cancer. 2011; 128(4):805-16.
전공분야 분자독성학
연구주제 Oxidative/cellular stress and gene regulation
Development of new biomarkers for cancer chemoprevention
Identification of novel biomarkers for target organ toxicity using metabolomics
Epigenetic regulation in a variety of model systems to underlying aging and inflammation
참여교수 명단
조동규 성명 조동규                
직위구분 참여교수
연구실번호 031-290-7782
연구실주소 -
이메일 jodg@skku.edu
홈페이지
사업참여기간  
경력 2002 - 2003 : GIST, Postdoctoral Fellow
2003 - 2007 : National Institute on Aging, National Institutes of Health, USA Postdoctoral Fellow
2007.03 - 2011 : 성균관대학교 약학대학 조교수
2007 - 현재 : 한국응용약물학회: 재무간사, 학술간사
2011 - 현재 : 성균관대학교 약학대학 부교수
2011 - 현재 : 대한퇴행성신경질환학회: 학술위원, 기획이사
2012 - 현재 : Biomoleules & Therapeutics: Associate Editor
2012 - 현재 : Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University; Associate Professor
2013 - 현재 : PLoS One: Academic Editor
논문 Gwon AR et al. (2012) Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer’s disease. Aging Cell 11, 559-68. (highlighted in cover)

Arumugam TV et al. (2011) Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the NFkB-Bim pathway in ischemic stroke. Mol. Pharm. 80, 23-31.

Wei Z et al. (2011) Notch activation enhances the microglia-mediated inflammatory response associated focal cerebral ischemia. Stroke 42, 2589-94.

Jo DG et al. (2010) Evidence that gamma-Secretase Mediates Oxidative Stress-Induced beta-Secretase Expression in Alzheimer’s Disease. Neurobiol. Aging 31, 917-25.
전공분야 신경생화학
연구주제 Molecular mechanisms of neurodegenerative diseases (Alzheimer’s disease, ischemic stroke, Parkinson'd disease) and brain aging.
Molecular mechanisms of diabetes and rheumatoid arthritis.
Identification of therapeutic targets of these diseases.
Development of new screening strategy and screening to discover new candidates of drugs
참여교수 명단
정지훈 성명 정지훈                
직위구분 참여교수
연구실번호 031-290-7783
연구실주소 -
이메일 jhjeong@skku.edu
홈페이지
사업참여기간  
경력 1995 - 1996 : 목암생명공학연구소, 연구원
2003 - 2004 : KAIST, Postdoctoral Fellow
2004 - 2007 : University of Utah, Postdoctoral Research Associate
2007 - 2011 : 성균관대학교 약학대학 조교수
2011 - 현재 : 성균관대학교 약학대학 부교수
논문 S. Y. Chae, H. J. Kim, M. S. Lee, Y. L. Jang, Y. Lee, S. H. Lee, K. Lee, S. H. Kim, H. T. Kim, S. C. Chi, T. G. Park, J. H. Jeong, “Energy-independent intracellular gene delivery mediated by polymeric biomimetics of cell penetrating peptides” Macromolecular Bioscience 11, 1169-1174, 2011. (*Featured as a cover article)

M. S. Lee, M. G. Kim, Y. L. Jang, T. G. Kim, S. H. Kim, T. G. Park, H. T. Kim, J. H. Jeong, “Polyethylenimine-g-poly(lactic-co-glycolic acid) as non-toxic micelle-type carrier for gene delivery” Macromolecular Research 19, 688-693, 2011.

M. S. Lee, Y. L. Jang, D. P. Huynh, C. T. Huynh, Y. Lee, S. Y. Chae, S. H. Kim, T. G. Park, D. S. Lee, J. H. Jeong, “pH-sensitive pentablock copolymer nanocapsules as nontoxic and efficient gene carrier” Macromolecular Bioscience 9, 688-693, 2011. (*Featured as a cover article)
전공분야 생물약제학
연구주제 Polymer-based drug delivery systems for biological molecules (nucleic acids, proteins, peptides)
Solubilization of poorly water soluble drugs
Gene therapy
Stem cell engineering and therapy
참여교수 명단
이정미 성명 이정미                
직위구분 참여교수
연구실번호 031-290-7784
연구실주소 -
이메일 jlee0610@skku.edu
홈페이지
사업참여기간  
경력 1999 - 2000 : 서울대학교 의과대학 연구조교
2003 - 2008 : UT Southwestern Medical Center, Research Assistant
2008 - 2009 : UT Southwestern Medical Center, Postdoctoral Researcher
2009 - 2010 : 성균관대학교 약학대학 초빙조교수
2010 - 현재 : 성균관대학교 약학대학 조교수
논문 Jia S et al. 2011, Simultaneous determination of 23 amino acids and 7 biogenic amines in fermented food samples by liquid chromatography/quadrupole time-of-flight mass spectrometry, J Chromatogr A, in press

Jia S et al. 2011, Non-derivatization method for the determination of gabapentin in pharmaceutical formulations, rat serum and rat urine using high performance liquid chromatography coupled with charged aerosol detection, Curr Anal Chem, in press

Jia S et al. 2011, Comparison of two aerosol-based detectors for the analysis of gabapentin in pharmaceutical formulations by hydrophilic interaction chromatography, Talanta, 85, 2301-6 Eom HY et al. 2010, Comparison between evaporative light scattering detection and charged aerosol detection for the analysis of saikosaponins, J Chromatogr A, 1217, 4347-54

Smithson DC et al. 2010, Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase, J Biol Chem, 282, 16771-81
전공분야 의약품분석학
연구주제 Bioanalytical researches focusing on
 · Green analytical chemistry-based method development
 · Analysis of small molecules (metabolites, drugs, and biologically active
substances)
Metabolomics-based study of various disease models
Multidisciplinary study on metabolic pathways in relation to diseases
참여교수 명단
김인수 성명 김인수                
직위구분 참여교수
연구실번호 031-290-7788
연구실주소 -
이메일 insukim@skku.edu
홈페이지
사업참여기간  
경력 2006 - 2007 : 성균관대학교 약학연구소 박사후연구원
2007 - 2009 : University of Texas at Austin 화학과 박사후연구원
2009 - 2012 : 울산대학교 화학과 조교수
2012 - 2012 : 경희대학교 약학과 조교수
2012 - 현재 : 성균관대학교 약학대학 조교수
논문 Satyasheel Sharma, Eonjeong Park, Jihye Park, In Su Kim* "Tandem Rh(III)-Catalyzed Oxidative Acylation of Secondary Benzamides with Aldehydes and Intramolecular Cyclization: The Direct Synthesis of 3-Hydroxyisoindolin-1-ones" Organic Letters 2012, 14, 906–909 (IF = 5.862)

Jihye Park, Eonjeong Park, Aejin Kim, Youngil Lee, Ki-Whan Chi, Jong Hwan Kwak, Young Hoon Jung, In Su Kim* "Rhodium-Catalyzed Oxidative ortho-Acylation of Benzamides with Aldehydes: Direct Functionalization of the sp2 C-H Bond" Organic Letters 2011, 13, 4390–4393 (IF = 5.862)

Jihye Park, Eonjeong Park, Aejin Kim, Seul-A Park, Youngil Lee, Ki-Whan Chi, Young Hoon Jung, In Su Kim* "Pd-Catalyzed Decarboxylative Coupling of Propiolic Acids: One-Pot Synthesis of 1,4-Disubstituted 1,3-Diynes via Sonogashira-Homocoupling Sequence" Journal of Organic Chemistry 2011, 76, 2214–2219 (IF = 4.450)

Soo Bong Han, Abbas Hassan, In Su Kim, Michael J. Krische* "Total Synthesis of (+)-Roxaticin via C–C Bond Forming Transfer Hydrogenation: A Departure from Stoichiometric Chiral Reagents, Auxiliaries, and Premetalated Nucleophiles in Polyketide Construction" Journal of American Chemical Society 2010, 132, 15559–15561 (IF = 9.907)
전공분야 약품합성화학
연구주제 Development of New Synthetic Methodology Based on Transition-Metal Chemistry
- Catalytic C-C or C-X Bond formation via C-H Bond Activation
- Catalytic Organic Transformations for Chiral Building Blocks
- Synthesis of Higher Value-added Materials from Various Feedstocks
Total Synthesis of Biologically Active Natural Products
Synthesis of Organocatalyst and Application to New Synthetic Methodology
참여교수 명단
윤유석 성명 윤유석                
직위구분 참여교수
연구실번호 031-290-7785
연구실주소 -
이메일 ysyoun@skku.edu
홈페이지
사업참여기간  
경력 2004 - 2006 : 성균관대학교 약학연구소 선임연구원
2006 - 2007 : University of Utah 약제학/약제화학부 박사후연구원
2007 - 2011 : 부산대학교 약학대학 조교수
2008 - 현재 : 한국약제학회 총무/기획/학술간사
2009 - 현재 : Korean American Pharmaceutical Scientists Association 편집간사
2011 - 현재 : 대한약학회 영문지 (Archive Pharm Res) 편집간사
2011 - 현재 : 성균관대학교 약학대학 부교수
논문 - Kim H, Lee J, Kim TH, Lee ES, Oh KT, Lee DH, Park ES, Bae YH, Lee KC, Youn YS. Albumin-coated porous hollow poly(lactic-co-glycolic acid) microparticles bound with palmityl-acylated exendin-4 as a long-acting inhalation delivery system for the treatment of diabetes. Pharm. Res. 2011:28(8):2008-19. (*Featured as a cover article)
Kim I, Kim TH, Ma K, Park ES, Oh KT, Lee ES, Lee KC, Youn YS. A 4-arm polyethylene glycol derivative conjugated with exendin-4 peptide and palmitylamine having dual-function of size-increase and albumin-binding for long hypoglycemic action. Regul Pept. 2011; 167(2-3):239-45.

Kim H, Park H, Lee J, Kim TH, Lee ES, Oh KT, Lee KC, Youn YS. Highly porous large poly(lactic-co-glycolic acid) microspheres adsorbed with palmityl-acylated exendin-4 as a long-acting inhalation system for treating diabetes. Biomaterials. 2011;32(6):1685-93.

Kim I, Kim TH, Ma K, Lee ES, Kim D, Oh KT, Lee DH, Lee KC, Youn YS. Synthesis and evaluation of human serum albumin-modified exendin-4 conjugate via heterobifunctional polyethylene glycol linkage with protracted hypoglycemic efficacy. Bioconjug Chem. 2010;21(8):1513-9.
전공분야 제제학
연구주제 Peptide and protein drug delivery (Oral, pulmonary, and nasal, etc.)
Drug delivery systems for diabetes/osteoporosis/cancer therapy (Hydrogels, nanoparticles, and microspheres, etc.)
Polymer conjugation technology for long-acting biopharmaceuticals
Inhalation delivery systems
참여교수 명단
김기현 성명 김기현                
직위구분 참여교수
연구실번호 031-290-7700
연구실주소 -
이메일 khkim83@skku.edu
홈페이지
사업참여기간  
경력 2011-2012 : 성균관대학교 약학대학 박사후연구원
2011-2012 : 성균관대학교 약학대학 시간강사
2012-2012 : 미국 하버드대학교 화학과 (Harvard University, Department of Chemistry & Chemical Biology) 박사후연구원
2012-2014 : Harvard Medical School, Department of Biological Chemistry & Molecular Pharmacology 박사후연구원
논문 -“Accelerated detection of mycolactone production and response to antibiotic treatment in a mouse model of Mycobacterium ulcerans disease”Converse, P. J.; Xing, Y.; Kim, K. H.; Tyagi, S.; Li, S.-Y.; Almeida, D. V.; Nuermberger, E. L.; Grosset, J. H.; Kishi, Y. PLoS Negl. Trop. Dis. 2014, 8, e2618.

-“4-Methylthio-butanyl derivatives from the seeds of Raphanus sativus and their biological evaluation on anti-inflammatory and antitumor activities” Kim, K. H.; Moon, E.; Kim, S. Y.; Choi, S. U.;Lee, J. H.; Lee, K. R. J. Ethnopharmacol. 2014, 151, 503-508.

-“Bioactive sesquiterpenes from the essential oil of Thuja orientalis”Kim, K. H.; Moon, E.; Kim, S. Y.; Choi, S. U.; Son, M. W.; Choi, S. Z.; Lee, K. R. Planta Med. 2013, 79, 1680-1684.

-“Lignan glucosides from Sinomenium acutum rhizome”Kim, K. H.; Moon, S. R.; Kim, C. S.; Woo, K. W.; Choi, S. U.; Lee, K. R. Biosci. Biotechnol. Biochem. 2013, 77, 2144-2147.

-“Polyphenols from the bark of Rhus verniciflua and their biological evaluation on antitumor and anti-inflammatory activities”Kim, K. H.; Moon, E.; Choi, S. U.; Kim, S. Y.; Lee, K. R. Phytochemistry 2013, 92, 113-121.

-“Pharbinilic acid, an allogibberic acid from morning glory (Pharbitis nil)”Kim, K. H.; Choi, S. U.; Son, M. W.; Choi, S. Z.; Clardy, J.; Lee, K. R. J. Nat. Prod. 2013, 76, 1376-1379.

-“Lanostane triterpenoids from the mushroom Naematoloma fasciculare”Kim, K. H.; Moon, E.; Choi, S. U.; Kim, S. Y.; Lee, K. R. J. Nat. Prod. 2013, 76, 845-851.

-“Butein is a novel anti-adipogenic compound”Song, N. J.; Yoon, H. J.; Kim, K. H.; Jung, S. R.; Jang, W. S.; Seo, C. R.; Lee, Y. M.; Kweon, D. H.; Hong, J. W.; Lee, J. S.; Park, K. M.; Lee, K. R.; Park, K. W. J. Lipid Res. 2013, 54, 1385-1396.

-“Phenolic constituents from the twigs of Euonymus alatus and their cytotoxic and anti-inflammatory activity”Kim, K. H.; Ha, S. K.; Choi, S. U.; Kim, S. Y.; Lee, K. R. Planta Med. 2013, 79, 361-364.

-“Isohericenone, a new cytotoxic isoindolinone alkaloid from Hericium erinaceum”Kim, K. H.; Noh, H. J.; Choi, S. U.; Lee, K. R. J. Antibiot. 2012, 65, 575-577.

-“Lignan constituents of Tilia amurensis and their biological evaluation on antitumor and anti-inflammatory activities”Kim, K. H.; Moon, E.; Kim, S. Y.; Choi, S. U.; Lee, K. R. Food Chem. Toxicol. 2012, 50, 3680-3686.

-“Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities”Kim, K. H.; Moon, E.; Kim, H. K.; Oh, J. Y.; Kim, S. Y.; Choi, S. U.; Lee, K. R. Bioorg. Med. Chem. Lett. 2012, 22, 6155-6159.

- “Three new fatty acid esters from the mushroom Boletus pseudocalopus" Kim, K. H.; Choi, S. U.; Lee, K. R. Lipids 2012, 47, 593-599.

-“In vitro metabolism of corydaline in human liver microsomes and hepatocytes using liquid chromatography-ion trap mass spectrometry”Ji, H. Y.; Lee, H.; Kim, J.-H.; Kim, K. H.; Lee, K. R.; Shim, H. J.; Son, M.; Lee, H. S. J. Sep. Sci. 2012, 35, 1102-1109.

-“Cytotoxic steroids from the trunk of Berberis koreana”Kim, K. H.; Choi, S. U.; Kim, C. S.; Lee, K. R. Biosci. Biotechnol. Biochem. 2012, 76, 825-827.

-“Gymnopilin K, a new cytotoxic gymnopilin from Gymnopilus spectabilis”Kim, K. H.; Choi, S. U.; Lee, K. R. J. Antibiot. 2012, 65, 135-137.

-“A new flavonol glycoside from Hylomecon vernalis”Lee, S. Y.; Kim, K. H.; Lee, I. K.; Lee, K. H.; Choi, S. U.; Lee, K. R. Arch. Pharm. Res. 2012, 35, 415-421.

-“Turtschamide, a cytotoxic putrescine bisamide from Corydalis turtschaninovii”Kim, K. H.; Choi, S. U.; Lee, K. R. Tetrahedron Lett. 2012, 53, 1490-1492.

-“Cytotoxic triterpenoids from Berberis koreana”Kim, K. H.; Choi, S. U.; Lee, K. R. Planta Med. 2012, 78, 86-89.
전공분야 천연물화학
연구주제 - Isolation and structure of natural products
- Chemical biology of natural products